Weight Loss Medication: Zepbound ®

Zepbound ® (active ingredient tirzepatide) is a GLP-1 GIP medication which contains the active ingredient tirzepatide. It is a once-weekly injectable medication that is FDA approved for weight management in people with a Body Mass Index (BMI) greater than 30 or a BMI greater than 27 with at least one weight related co-morbidity (condition). Zepbound ® works by activating stimulate both native GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptors in your body. By targeting these pathways, Zepbound® helps to control appetite, reduce food intake, and improve how your body processes sugar and fat. This leads to more effective and sustainable weight loss when combined with healthy lifestyle changes.

Combination GLP-1 GIP medications are not stimulants nor habit forming, and produce a variety of unique benefits to promote weight loss, health, and well-being, including:

For more information, visit Zepbound ® | Eli Lilly and Company .

In a study published in JAMA (December 2023), Zepbound® (active ingredient tirzepatide) showed mean weight loss of over 25% after 88 weeks and mean weight loss of nearly 21% after 36 weeks. Needless to say, those are positive outcomes that impact not only weight and quality of life, but a host of weight associated diseases and headwinds for optimization of longevity.

While both Zepbound ® (active ingredient tirzepatide) and pure GLP-1 agonists are effective weight loss medications, they differ in their formulations and mechanisms of action. Zepbound® contains tirzepatide, which activates both GLP-1 and GIP receptors in the body. This dual-action approach targets multiple pathways involved in energy regulation, leading to effective and lasting weight loss. Zepbound®’s dual-receptor activation offers potentially broader benefits in weight management compared to the pure GLP-1 agonists.

For more information, visit Zepbound ® | Eli Lilly and Company .

Yes. Both GLP-1 and GIP peptides (short proteins) exist naturally within the body. They may help to restore healthy weights in combination with complimentary lifestyle changes.

Weight management medications are by no means required to participate in a JumpstartMD weight management program. In fact, many of our members pursue their weight management journey without medication and our published outcomes study on over 22,000 members showed that they also do remarkably well.

Starting at the first appointment, our members learn that losing weight – and keeping it off – is about making smart decisions based on nutritional science. Members lose an average of 26 pounds (12.6% of their starting weight) by month 6.

Research shows that, in combination with health coaching and lifestyle changes, new generation medications like Zepbound® , Mounjaro ® , Wegovy ® , Ozempic ® and others can be both safe and extremely effective at promoting long term, successful weight loss.

Learn more about each medication’s benefits and risks by visiting the manufacturer’s Prescribing Information webpage prior to starting any weight loss program.

Medications like Zepbound ® (active ingredient tirzepatide) help control your appetite and improve how your body uses energy, which can lead to weight loss and improved health. While healthy lifestyle changes are crucial for sustainable weight loss, losing weight and keeping it off can be really hard. A recent study showed that patients who stopped taking Zepbound ® regained 14% of their weight within a year. Using medications like Zepbound® can make it easier to reach and maintain a healthy weight, leading to better overall health and preventing serious diseases.

For more information, visit Zepbound ® | Eli Lilly and Company .

Average full-retail price of Zepbound ® (active ingredient tirzepatide) is currently around $1,300 per month. Our experts can assist in determining eligibility for savings programs or insurance coverage, which can reduce the cost to $25 per month.

For those interested in GLP-1 insurance coverage or discounting, discuss options with your JumpstartMD clinician, and we can then partner to determine how best to proceed. You may also visit Savings Card, Cost & Coverage Support | Zepbound to learn more.

We are also able to offer other cost-effective options for members whose insurance does not cover a particular medication.

Zepbound ® (active ingredient tirzepatide) is FDA-approved for treatment of type II diabetes. JumpstartMD and your doctor can help determine if you are a good candidate for Zepbound® depending on a number of factors, including your body mass index (BMI) and health history.*

For more information, visit Zepbound ® | Eli Lilly and Company .

If you’re interested in trying Zepbound ® (active ingredient tirzepatide) for weight management, it’s important to discuss that option with your JumpstartMD healthcare provider to see if it’s a good option for you. Your JumpstartMD clinician will consider your medical history, current medications, and other factors before making a recommendation.

For more information, visit Zepbound ® | Eli Lilly and Company .

Like all medications, Zepbound ® (active ingredient tirzepatide) can cause side effects. The most common are nausea, with less frequent occurrences of vomiting, constipation, or other gastrointestinal symptoms. Our clinicians can prescribe medication to manage these side effects, which typically subside on their own after a few days or weeks.

For more information, visit Zepbound ® | Eli Lilly and Company .

Zepbound ® (active ingredient tirzepatide) and Mounjaro ® (active ingredient tirzepatide) are the only GLP-1 GIP brand medications on the market today. Zepbound ® is approved for weight management for people with a BMI over 30 or over 27 with conditions like high blood pressure, high cholesterol, or pre-diabetes. Mounjaro® is approved for treating type II diabetes.

For more information, visit Zepbound ® | Eli Lilly and Company and Mounjaro ® | Eli Lilly and Company .

If your insurance doesn’t cover a GLP-1 GIP dual-agonist, don’t worry! Our clinicians are experts in medical weight management and have a full range of medications they can prescribe to help you achieve and maintain your health and wellness goals. We are also able to offer other cost-effective options for members whose insurance does not cover a particular medication.